Metabolism of Carbohydrate in the Depan- Creatized Dog

It has generally been accepted that there is no rise in respiratory quotient following the ingestion of carbohydrate by the depancreatized animal and that the administered sugar is quantitatively excreted. However, careful scrutiny of the literature reveals a surprising number of cases of apparent oxidation. Falta, Grote, and Staehelin (13) reported no rise in R.Q. following glucose ingestion, but they recovered only 65 per cent of the administered sugar. VerzAr and von Fej& (27) presented a series of ten experiments performed on the 4th to the 19th day after pancreatectomy; of these, one dog had an average glucose R.Q. of 0.78 after a basal of 0.71. The remaining nine were negative save for the fact that, in one other animal, a basal R.Q. of above 0.75 was obtained. In this case glucose produced no rise. In another group of experiments reported by Verz&r (26) no change in quotient was found in five glucose tests after the 3rd postoperative day. On the 1st and 2nd days following extirpation of the pancreas, elevated quotients were invariably obtained after glucose injection. Eight glucose experiments were performed by Moorhouse, Patterson, and Stephenson (20) on the 3rd to the 14th day after operation. One of these showed a rise from 0.74 to 0.77, while six exhibited no change. In the remaining one, glucose produced an elevation in R.Q. from 0.73 to 0.80, but the next day, without any glucose, quotients varied from 0.62 to 0.84. Recoveries ranged from 75 to 100 per cent, averaging 93 per cent, but the low recoveries were not coincident with the heightened quotients. HBdon (15) contributed a series of seven experiments in which